The Gladden Longevity Podcast
The Gladden Longevity Podcast
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      • E10-Autumn-Calabrese
      • E13-Scott-Bertrand
      • E15-Dr-Gladden
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      • E18-Ari-Tulla
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      • E47-Melisa-Karabeyoglu
      • E48-Dr. Stel-Nikolakakis
      • E49-Q&A: Steve + Dr. G
      • E50-Ian-White
      • E51-The Turnipseeds
      • E52-Sten--Stray-Gundersen
  • Home
  • Listen Now
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    • E10-Autumn-Calabrese
    • E13-Scott-Bertrand
    • E15-Dr-Gladden
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    • E17-Dr-Amy-Albright
    • E18-Ari-Tulla
    • E19-Dr-Gil-Blander
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    • E41-Steve-Reiter
    • E42-Katie-Ingram
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    • E48-Dr. Stel-Nikolakakis
    • E49-Q&A: Steve + Dr. G
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    • E52-Sten--Stray-Gundersen

Gladden longevity — Episode #47

Episode #47 — Melisa Karabeyoglu

Steve Reiter: Welcome to the Gladden Longevity Podcast with Dr. Jeffrey Gladden, MD, FACC, founder and CEO of Gladden Longevity. On this show, we want to help you optimize your longevity, health, and human performance with impactful and actionable information by answering three questions. How good can we be? How do we make 100 the new 30? And how do we live well beyond 120?


I'm Steve Reiter and, Dr. Gladden, we just got done interviewing Melissa Karabeyoglu from Vivoo. And the company is spelled V-I-V-O-O, but it's Vivoo, and they have test strips that will test for electrolytes and protein in your urine and a whole bunch of other stuff. And this was-


Dr. Jeffrey Gladden: Yeah. Like oxidative stress and what your keto levels are, what your pH is, and things like that. I love this conversation, Steve. I think the audience is really going to enjoy this. This falls into the category for you to have real-time feedback on how you can optimize your hydration, your minerals, your supplements, your vitamin C levels, and whether or not you want to be ketotic or not. And also, I think, importantly, what is your level of oxidative stress? You're going to learn some really fascinating things here about how all this ties together.


We're used to real-time feedback with things like continuous glucose monitors and Whoops, and Oura rings, and Apple watches, et cetera, but this is another take on it, and all of a sudden, you're going to open up a window into more information about yourself that you didn't have access to. I think you're going to love this show.


Steve Reiter: And you used it this morning, and you-


Dr. Jeffrey Gladden: I did.


Steve Reiter: ... asked Melissa about some of the results, like your electrolytes were low.


Dr. Jeffrey Gladden: Yeah, you'll hear about that on the podcast. I learned some things, which was super fun. I was great in some things, but I needed some help that I didn't know I needed, and so that's the beautiful part of this. So, Melisa, it's great to have you on the Gladden Longevity Podcast. Looking forward to this conversation. So, tell us a little bit about how you got to be where you are today. I know you're a registered dietician and nutritionist and things like that. You have an interesting background in working with real food banks, and it sounds like homeless shelters and things like that in New York, which is really a fascinating place to bring nutrition.


Because when you think about people that are nutritionally depleted, it's going to be people that are living that lifestyle, but then also the food that they have access to is typically calorie-rich and nutrient-poor. So, that must have been a fascinating thing. So, tell us a little bit about that and then maybe how you got to where you are today.


Melisa Karabeyoglu: All right. Thank you. It's wonderful to be here, Dr. Gladden. Thank you for that warm introduction. So, you are correct. I have a lot of different areas of expertise in the field of nutrition, and I did start off in public health. When I was sitting at Johns Hopkins, I did research at the Bloomberg School of Public Health. I was awarded a scholarship, and I got very into public policy. And then, when I was living in New York City, I did work with the Department of Health for New York State and also the food bank. I was responsible for not only creating menu plans but also for teaching lessons in English and Spanish.


My passion for nutrition kept on increasing, and then I realized if I wanted to get involved at a larger level, I would need to pursue a doctorate and also get involved in policy change. When I was doing my Ph.D., which I'm still doing right now, I was also learning more and more about how individuals on our day-to-day lives were actually really low in a lot of key nutrients. And that's how I started working for Vivoo, which is why we're here to talk to today.


Dr. Jeffrey Gladden: Yeah, okay. So, Vivoo, just so the audience understands, Vivoo is spelled V-I-V-O-O, and it is a home urine test that can be utilized to look at sort of nutrient status if you will, and we can talk a little bit about that. So, I'm just curious about the thoughts that you had with working with the government departments and things like that. I mean, do you think it's really... I saw something in your resume about just choosing fruits and vegetables, just saying yes to fruits and vegetables, or something like that, which I thought was cool. And I thought that in that population of people, access is a big issue. Did you come away with any breakthroughs for them or any ways to get them actually more nutrient-dense foods?


Melisa Karabeyoglu: Yeah, thank you. So, we always encourage the increased consumption of fruits and vegetables. Unfortunately, with the Western American diet or the standard American diet, the SAD, there's a lot of consumption of processed and packaged food, and a lot of families actually, although they could not afford to eat out, they actually didn't know how to cook their own foods at home. We were constantly increasing the consumption of fruits and vegetables, whether it was at a farmer's market or there was also the initiative done by New York State where in the downtown city centers we have our, I call them the healthy fruit stands, so you can go and just purchase a banana for 50 cents.


We were constantly trying to encourage populations to have fruits and vegetables accessible, even in food desert populations, even in Manhattan. Some areas are food deserts because there's just so much restaurants and to-go stores. There are not actually a lot of supermarkets, and if there are supermarkets, they're usually not affordable. When I was doing that, I realized how much individuals were lacking proper kitchens and enough time. Both parents were working and also the cooking skills. So, I started off as a dietician and a chef, but then I wanted to develop more and more initiatives throughout the government. 


So, that's somewhere in my future career prospects. And currently, right now I'm trying to learn about how to improve my diet on an individual level. I have my own private practice, and I counsel a lot of clients. Most of my clients are still actually in the New York City metropolitan area, and we talk about the importance of cooking your own food at home and making realistic goals.


Dr. Jeffrey Gladden: Let me interrupt this for a second, but that is a real challenge for people to cook. So many people are busy, right? 


Melisa Karabeyoglu: Yeah.


Dr. Jeffrey Gladden: Everybody's a busy professional; a lot of our clients are busy, professional, a lot of people listening to that are in sort of the biohacking space and actually a new space that we're going to open up called age hacking. But I think that in that space, being able to prepare food or prepare food on a Sunday that's going to carry you through the week or doing some things like that, I've gotten into this routine where I get... right now, I go to the store and get what I can get. 


So, I have some basil, some spinach, and some kale. They didn't have any fresh arugula that I was interested in, things like that. But I'll throw them in a pot and just take a large volume and condense it down, not cooking the nutrients out of it, just enough to get it condensed, so I can eat a lot of veggies in the course of a day by doing it that way. But it only takes about five minutes to do that, quite honestly. So, that's one of the hacks that I've figured out about how to get more volume in with kind of minimal effort, if you will. Do you have any hacks like that that you'd recommend for people?


Melisa Karabeyoglu: So, I love that hack of yours. I actually saw that on your Instagram page, and I thought that was fantastic because our generation is so obsessed with making smoothies, and it is easier to digest the food when you do blend it and make it into smaller particles. But actually one of the purest ways you can cook greens is to slowly just cook away the water. A lot of fruits and vegetables are 70 to 90% water, and we're constantly trying to be hydrated, and that's what I love with Vivoo. We can test our hydration, which obviously it matters every day, your hydration, but also within hours. 


And as we age, the percentage of water in our body decreases. When we're newly born, it can be 70 or 80%, and when we're in our late years, it can go all the way down to 60%. So, I always tell my clients to eat their water. And I think a lot of individuals can get overwhelmed when they look at a huge amount of spinach or greens, but when you cook them down, all of a sudden, you go: "Oh, wow, I think I could eat that." You know?


Dr. Jeffrey Gladden: Right. Exactly.


Melisa Karabeyoglu: That's a great hack you have. Yeah, it's much more approachable and tasty.


Dr. Jeffrey Gladden: Yeah, exactly. And tasty. It's super tasty, actually. It makes the whole kitchen smell good too. So, that's interesting—this idea of eating the water. So, let's talk about water for a minute, and let's talk about Vivoo. So, we all know that hydration's important. One of the parameters that Vivoo measures is the level of hydration. And let's just describe how the Vivoo... I'll describe how it works because I did it this morning. Basically, it's a strip in a packet. You pull out this test strip. It's not like any other urine dipstick that you've seen before in a doctor's office or anything else.


It's kind of multicolored, multi-hatched, whatever, and you end up urinating on it, sort of midstream urination, and then you hold it up to your phone's camera and take a picture of it. Or actually, the app automatically, the Vivoo app automatically took a picture of it for me, and then from there, it analyzes, I'm assuming, all the different colors and saturations or whatever, intensities. And from that, it ends up making a report based on ketones and certain minerals and hydration and some other things. So, I'm a huge fan of real-time feedback for people. So, continuous glucose monitors, I think, are massively important for people to actually understand what's going on when they eat something. 


But I think this is fascinating too because we have a lot of people that are listening and are avid exercisers and take their health very seriously. And I'm exercising, doing something every day, virtually every day. So, I did a workout this morning, actually before I did the test, and then I have a strategy around water where I do drink through the day, but some of it's green tea, some of it's pure water, some of it's hydrogen water. And I also have a strategy for staying hydrated at night where when I get up to urinate, I also drink water again, so that I don't wake up dehydrated. So, I was interested to see that my water score on the app was at a hundred percent and that I was a hundred percent hydrated. And I thought: "Well, that's-


Melisa Karabeyoglu: Wonderful.


Dr. Jeffrey Gladden: Yeah. But that's interesting to see. It's like: "Oh, okay, this stuff that I'm doing is working." So, I think, for the listeners, if you're waking up with a dry mouth or you're feeling like: "I wonder if I'm getting enough water," this can be a good way to do it. So, tell us a little bit about some of the other things that this can measure besides just hydration.


Melisa Karabeyoglu: So, thank you for sharing your hydration score. That's very impressive. Vivoo does test hydration. It tests nine parameters in total. So, that's great, by the way, that your results are showing that you're hydrated. It's probably because you're consuming so many different sources of water and throughout the day. Water can be one of those hard test scores to hit a hundred percent, so congratulations. 


Dr. Jeffrey Gladden: Oh, really? Okay. I didn't know that.


Melisa Karabeyoglu: So, we also... Yeah. Just because I think a lot of individuals are trying so hard to drink their water, and then they're not seeing the results show. Maybe they're not drinking the water with enough electrolytes, maybe they're drinking it with their meals, or maybe they're drinking it too much in one go. So, I think you have a really great regimen.


Dr. Jeffrey Gladden: I do try to drink throughout the day. I'm sipping on something-


Melisa Karabeyoglu: That's excellent.


Dr. Jeffrey Gladden: ... here while we're talking. You see-


Melisa Karabeyoglu: Oh, wonderful. 


Dr. Jeffrey Gladden: Yeah. 


Melisa Karabeyoglu: Yeah, I think with Vivoo, what's really interesting is, like you were saying, it's great to just have that confirmation. You're seeing that all these activities that you're doing throughout the day are having a positive reflection internally, so you're able to see how that is. So, with urine tests, the difference with blood lab tests, the doctor would say: "We would like to test these lab values." You would go, you would give a blood sample and also sometimes a urine sample. But with Vivoo, we're showing daily results of what your kidneys are really excreting. 


So, we also look at vitamin C, which is a water-soluble vitamin. So, it's very important for everyone to monitor their vitamin C intake just because since it is a water-soluble vitamin and it's not a fat-soluble vitamin, we have to make sure that we're eating it every single day.


Dr. Jeffrey Gladden: Right.


Melisa Karabeyoglu: And we hear about it a lot with COVID, et cetera, for keeping our immune system strong, but beyond that, it's just a great antioxidant, and it's really important for longevity, for collagen synthesis, for any kind of process relating with skin and tissues and joints. So, it is really essential. And men would need around 90 milligrams; for women, we would say 75 milligrams. If you're smoking, you would need more just because smoking does produce a lot of free radicals, and vitamin C is an antioxidant. A lot of the antioxidants from vitamin C would work to neutralize those free radicals from smoking.


Dr. Jeffrey Gladden: One of the other interesting things it's not only "eat your water," I think it's" eat your vitamin C."


Melisa Karabeyoglu: Yes. 


Dr. Jeffrey Gladden: Because vitamin C that shows up in a plant is different than the vitamin C that you get in the health food store that-


Melisa Karabeyoglu: Totally, yeah.


Dr. Jeffrey Gladden: There's a misnomer about that. Ascorbic acid is really the centerpiece of vitamin C, but it really is a whole constellation of molecules. And so, when you eat it and get vitamin C that way, as opposed to just taking ascorbic acid... Actually, vitamin C is an antioxidant, but when you take ascorbic acid in high doses, it's actually an oxidant. So, it's used to treat cancers, and it's used to treat infections. So, just keep that in mind that if you're trying to optimize your vitamin C, it's not about going to the store and taking pills. It's really about eating not only your water but your vitamin C. So, I will share this. My vitamin C was also 10 out of 10, which was optimal. 


Melisa Karabeyoglu: Yay. Congratulations. 


Dr. Jeffrey Gladden: But I'm going to tell you about the things that weren't optimal. Well, oxidative stress was also optimal at ten out of 10, and my ketones were optimal this morning at ten out of ten, probably because I was fasting. But let me tell you about what wasn't optimal. My magnesium was low. You had five out of 10. My calcium was low at five out of 10. My sodium was low at four out of 10. And I think that this is really interesting information for me because I do saunas on a fairly regular basis. 


I don't have access to it every day, but I'm pretty good about that. I live in a climate that's warm, currently in Puerto Rico, and I oscillate between Puerto Rico and the US, but I'm out running, I'm sweating profusely, and I come back. My clothes, it's like I just jumped in the ocean, but I haven't yet, but I will if I come back from a run. Point being, when you perspire a lot, and you're exercising a lot, I don't think I'm actually repleting my minerals nearly enough. Right?


Melisa Karabeyoglu: Yeah. It's great you're taking that point. So, a lot of individuals should be exercising as you are, and that's fantastic. I saw on your website it seems that you really do practice what you preach. So, by the way, that's amazing, everything you're doing. But a lot of the minerals, like you're saying, for example, calcium, magnesium, we test those along with sodium, and it's really essential to replenish those. So, we always think of sodium because we're salting, but also just because sodium is really responsible for the regulation of fluids, and it's really found outside of our cells, in our interstitial fluids, so it's really important to make sure that we're eating salt.


We actually have an excellent speaker, and I'll send you some of his podcasts. And he just talks about how it's salt; we're always told that salt is vilified like fat, was in the '90s when it was really bad. And a lot of us actually may be deficient in salt, especially if they're like yourself, a health enthusiast. And also, if you're not consuming processed food or if you're not consuming a lot of meat, dairy, and eggs, you might actually be low in salt. So, if you are consuming more plant-based and you're also sweating like you are, being very active, you might be low also on salt, and you might need to add it to your meals, which sounds really contradictory. And I feel like everyone's listening; they're saying: "A dietician's telling me to add salt to my meals." But we might need to, yeah.


Dr. Jeffrey Gladden: And that's the beauty of being able to test it because otherwise, you don't know. It's not like I feel like I'm hyponatremic, low on sodium or magnesium. I can't really tell per se, but to be able to test that and actually see it and then make a trajectory change because of it that's powerful. That's powerful information like that.


Melisa Karabeyoglu: Yeah. So, as you know, of course, since with your education, obviously you know calcium, magnesium, they go hands-in-hands and both of those minerals, sometimes an individual might be great on calcium and low on magnesium, but with calcium, a lot of the time also, it's just really... All these minerals are important for our body, and we don't really realize that minerals actually never go away. If you burn them, they're inorganic, and they don't have carbon. So, they're in ashes and everything, but we have to constantly consume them. 


And we always think of calcium from dairy, and you can definitely get calcium from dairy and eggs, but it's actually present also in greens and broccoli, anything dark-colored and dark green-colored. And you can also... So, I'm sure that delicious dish you make of wilted greens, that has a ton of calcium. That's a calcium depot. And if you were cooking it even in a cast-iron skillet, you would get the iron also from the skillet and getting your iron, I always love to talk about, like you were saying, instead of going for vitamin C in a conventional form which we are marketed to consumers, think about how we naturally have been consuming it for years for seasonal fruit. 


Just the same thing with minerals. A lot of ancient food practices have tons of minerals present in the food due to agricultural and just genetic modification. A lot of our soils are deficient in a lot of minerals, so we have to go to an extra step and add them into our diet. In addition, an individual like yourself who is sweating out a lot, every time we're sweating, what are we losing? We're losing fluid, but we're also losing electrolytes. We have to replenish them, just like we drink when we get out of the sauna.


Dr. Jeffrey Gladden: It's an interesting thought because we think a lot about nutrient density. I think a lot about nutrient density and the fact that it's difficult to get nutrient-dense foods. Even organic foods are not terribly nutrient-dense sometimes, depending on, to your point, the soil that they're grown in, the time of year that they're grown, and things like that. But also, when you think about nutrient density, it's not just about phytochemicals and vitamins; it's also about the mineral content. And I haven't been thinking quite as much about the mineral content as I have the other elements of nutrient density, so to speak.


I think that what was recommended to me by the app, the app also makes some recommendations. It was recommending that I eat some okra, I believe. Was some okra. It's basically in me, calcium. I was also a little bit acidic in my pH. It was recommending raspberries to [inaudible 00:20:08]. Doing some things like that. But what about magnesium and calcium? Do you have sources of magnesium that you like that people can go to?


Melisa Karabeyoglu: Yeah. I think magnesium is one of those minerals that we hear about more. We've all heard about calcium because we're constantly pushed by the USDA to increase our dairy, and it's just drink your milk, et cetera. We heard about magnesium about ten years ago just because the supplement industry has... pushing us to buy magnesium, and it's also really essential, though, if you do work out, just because it's necessary for our muscles to function properly along with our nerves. That's why we always tell our... If you do take an additional supplement to supplement in the night, just so you can relax the night, your muscles and your nerves will relax.


In terms of food, magnesium is actually really rich in chocolate. If you were to eat raw cacao, and since you are in Puerto Rico, if you could go to maybe a little bit like Costa Rica and get some real raw cacao that's really, really rich in magnesium, of course, depending on the soil and also a lot of legumes. So, a lot of beans are really rich in minerals and in addition to grains. So, we would always suggest having grains, nuts, seeds, and legumes. They are rich in magnesium, yes.


Dr. Jeffrey Gladden: Yeah, that's right. I think pumpkin seeds are actually very rich in magnesium.


Melisa Karabeyoglu: Yes. Yeah.


Dr. Jeffrey Gladden: They're, in fact, they're a great source of magnesium.


Melisa Karabeyoglu: Yes.


Dr. Jeffrey Gladden: When you start to talk about legumes, there's this concept about lectins that always pops up for people. "Should I be avoiding lectins or not avoiding lectins?: What's your take on the lectin story? Is this something we should be aware of, or what?


Melisa Karabeyoglu: Yeah. So, I love that book, and I remember I was very interested in that; I love the grain brain. And I do believe that for me, I'm very interested in cultures around the world, and I love traveling, and I love talking. When I go there, I love to go and talk with the older people who are still preparing the food the way they were taught by their grandmother, and then I see these ways that they were cooking certain food groups, for example, legumes in a way that naturally can remove the lectins and phytates.


So, they always soak their legumes, they always throw off the foam. A lot of them will scoop off the foam constantly. And I do believe that legumes and beans, yes, they do have lectins. However, there are a lot of different cooking methods that can dramatically decrease them, and their health benefits are very great.


Dr. Jeffrey Gladden: Yeah, that's my take on it as well. I think if you're eating raw beans or some of the foods that are high in lectins raw, it's an issue. But if you actually cook those, then you kind of destroy... you denature of the lectins, and you can get past them. And I think people have mislabeled foods. Beans and legumes, I'm never going eat those because they have lectins in them, but in actual fact, they're short-changing themselves if you cook them properly, and now all of a sudden, you're missing all these sources of different minerals.


And beans and rice, of course, are a perfect protein combination, things like that. So, I think we need to be careful when we hear about something related to foods in the sense that we don't want to be excluding foods because what I think and what we've seen with a lot of food sensitivity testing is that it's the people that have the broadest range of foods in their diet that seem to have the least food reactivity because the immune system isn't seeing the same thing every day.


And so, I think it's also important to have nutrient variety. And I try to counsel people that what your body really loves is variety, so give it as much variety as possible, maybe with the exception of ice cream and pie. But anyway...


Melisa Karabeyoglu: I think that's a great point. Now with economic problems worldwide, people are, for the first time in a long time, really watching how much they eat of food groups, in Europe. And right now, I'm in Europe and Asia, and meat and dairy prices are so high. It's very inexpensive in America, so people are consuming it very carefully. You have a little bit of everything, and we used to live in larger families, and we couldn't sit down and eat 30 almonds, 40 almonds, or for instance, eat huge tablespoons of almond butter.


A lot of these foods which are so easily available in our modern lifestyle haven't been available to us for so many years in such large isolated amounts. So, I do think a lot of these sensitivities are happening because we are, like you said, not having a very well-balanced diet. And living alone or not having the proper education, not learning from your grandmother or grandfather can also have a really big impact on that.


Dr. Jeffrey Gladden: That's a good point that you make. I think that the fact that we have access to high quantities of a single item, whether it's cashews or almonds or walnuts or spinach or anything else, right?


Melisa Karabeyoglu: Yeah.


Dr. Jeffrey Gladden: The fact that it's really nuts. So, I think if you're listening to this, I think one of the things you want to do is broaden your reach when it comes to things that you include in your diet. Every time I go to the grocery store, I try to buy different things just to mix it up, both from a standpoint of my palate, but also I know that it's good for my immune system and also it's good for getting different nutrients at various times. So, I think that's a good takeaway. With the whole Vivoo thing, what's the mission here? What are you guys trying to actually accomplish? What's the big picture?


Melisa Karabeyoglu: That's a great question. So, I think something really beautiful that the CEO and founder always mentions is that she really wanted to make wellness accessible and affordable. It's a very light and easy-to-carry strip. You can take it with you wherever you go, anywhere. I take it when I travel all the time, which always shows that I'm dehydrated, by the way, when I'm traveling. And it allows a lot of people to access data that they would not otherwise have the opportunity to.


Some individuals have a really hard time even going to get a simple blood test done once a year, and then they realize that their magnesium levels are low, et cetera, et cetera. So, it's a really exciting approach, is that you're able to have this individualized data based on your internal structure and seeing how your body is responding. Now we know that your carefully-thought-out water regimen is really functioning well for your body. Maybe for another individual be, they might be-


Dr. Jeffrey Gladden: Correct. And they- 


Melisa Karabeyoglu: ... over-hydrated or under-hydrated.


Dr. Jeffrey Gladden: Right, exactly.


Melisa Karabeyoglu: So, it's showing you proof, and also, I think it's biohacking. So, I know you were mentioning that you also... Before we started recording, you were saying that you use the ring. These are all different tools that we have invented to allow humans to connect better with their bodies. I always say I wish... This is my own point. I wish that in our school education, we were taught so many things. I wish we were taught more about also money management, but I also wish we were taught more about health and more about how all our lifestyle choices impact our bodies. I wish we were given a little bit more of a medical knowledge in our high school education.


Dr. Jeffrey Gladden: No, I agree with you. I was just thinking, as you're saying that, that one of the best ways to do that every kid in junior high or high school has a health class, but it's just information. I mean, what would be fascinating for them would be to see their own bodies on a Whoop or an Oura ring or using Vivoo, use that for the semester and see how it changes their activity levels, their dietary, their sleep patterns, all these things and really start to set them up for success earlier in life. It'd be really interesting to actually almost start a not-for-profit or something to introduce kids to this kind of real-time feedback.


Melisa Karabeyoglu: Yeah. So, real-time feedback, exactly. And I think in this really quick-paced life we're living in, everything is about real-time and how it's working, and you can be talking with someone in a different country on a different platform like we're doing right now, and everything is so... We're looking at nutrient-dense food, how to get the most from each meal. And also, this is just another type of tool that you can use on how to get the most from your actions and your lifestyle choices.


So, for me, I find it very motivating because it's similar to having nutrition or a personal coach or a doctor that's a close friend that can be like: "Look, this is working well for you. You're absorbing vitamin C." Or: "Look, you're not getting enough magnesium from your diet." So, that's great. And also, you mentioned that your oxidative stress is great. I love that because I'm very interested in inflammation, so I always look at oxidative stress. And I also love pH. I find that that's really important. Research shows that when we have a more alkaline diet, it's harder for infectious diseases and even cancerous cells to grow. And-


Dr. Jeffrey Gladden: That's great.


Melisa Karabeyoglu: ... I think the whole, what you were saying before, it means a lot when it's about you. We hear in the news about this and that, but when it happens to a close friend, one of our friends gets cancer, and all of a sudden, cancer becomes important. When you're on your phone, and you are scanning this after you take the test, and it shows magnesium, all of a sudden, you think: "Wait, what was magnesium?" You Google it. It makes it more important. 


Dr. Jeffrey Gladden: Absolutely.


Melisa Karabeyoglu: So, when you get these individualized results, it makes you much more motivated. I'm a dietician, and unfortunately, a lot of individuals come to me thinking that I'm going to help them get to a weight loss goal. I always focus on health instead of a number on the scale, and I think that-


Dr. Jeffrey Gladden: True.


Melisa Karabeyoglu: ... these tools are great because they're putting a revolution. Instead of just focusing on what's on the outside of someone, we're actually getting a chance to look inside and see what's going on.


Dr. Jeffrey Gladden: I think to that point, one of the things that you talked about was when you travel, you notice that you're more dehydrated. And airplane travel, in general, is dehydrating for a couple different reasons. One is that the humidity inside the plane is at 20%, which is very low humidity. The other is that you're at 8,000 feet and when you're pressurized to 8,000 feet, even though the plane's at 35,000, the cabinet is pressurized at 8,000 feet. When you go to 8,000 feet, it basically changes the pressure inside your thoracic cavity, and your body responds to that by releasing a diuretic hormone, a brain-derived neurotrophic factor. 


And so, you're actually urinating more when you're on the flight. And if you go to an elevated altitude, let's say your destination is Aspen or someplace, you're going to be urinating a lot more there. So, when people say you're going to elevation, you need to drink a lot of water, it's true, but it's also true on a flight. So, we love hydrating before we get on the plane, drinking hydrogen on the plane, hydrogen water on the plane to protect you from radiation, and also hydrate. And then what I do is, I drink another hydrogen when I get off. Because when you get off of a flight, you always feel a little groggy somehow. I don't know if you're like that? 


Melisa Karabeyoglu: Yeah. 


Dr. Jeffrey Gladden: But when you drink the hydrogen water, it kind of reboots you, and also you're rehydrating, and it's also alkalizing your urine, and so, all of a sudden, you start to feel good again. So, that's important for people to understand when they travel; it's another challenge to your hydration, just like exercise is another challenge.


Melisa Karabeyoglu: Yeah, that's really great what you're sharing. And I feel like a lot of individuals are, number one, afraid to use bathrooms outside of their house in general. Number two, especially in airports and planes, because it's more dirty in their mind. So, they're like: "I don't want to drink a lot of water because then I have to make the person next to me get up, and then I have to go into the small little thing." And then they have-


Dr. Jeffrey Gladden: Interesting, yeah.


Melisa Karabeyoglu: And then some-


Dr. Jeffrey Gladden: It's a male versus female thing, too, I don't know.


Melisa Karabeyoglu: Possibly. And also, it's like you're like: "Hi, can I have three more of those really small water bottles?" And then the hostess looks at you like: "Ugh, her." So I, no one really hydrates well, but you're right. I mean, after the plane, I didn't know, those are amazing facts you shared. I knew about our internal structure, but I didn't know about the feet change, but we just feel really dehydrated. Even in my knuckles, I'll see that I look dehydrated, and I feel that grogginess. So, I'm going to hydrate even more now, which I didn't think was possible on the plane.


Dr. Jeffrey Gladden: Yeah, no, good for you. Good for you.


Steve Reiter: This episode of the Gladden Longevity Podcast is brought to you by H2, Molecular Hydrogen in the Gladden Longevity Store.


Dr. Jeffrey Gladden: Yeah. Steve, you've heard us talk about this numerous times on the podcast, in terms of the benefits of H2 and hydrogen water. We love it. It's really the best way to balance your entire redox system, so it really protects you from free radical damage. I take it every time I get on a flight to protect me from radiation damage when I'm flying, and I use it to rejuvenate my brain in the afternoon. There's really two kinds of exercise. There's physical exercise, and taking H2 before or after that works great, but also, there's a mental exercise. And I find that the H2 will bring your brain back when you're tired in the afternoon. So, I think it's the perfect thing for longevity and for performance, quite honestly.


Steve Reiter: And I talked to you about this, that I found dropping one to two tablets in a glass water bottle right before bed, I've seen an overall bump in my deep sleep when I do so. So-


Dr. Jeffrey Gladden: Fascinating, yeah.


Steve Reiter: So, if you click on the store tab when you visit gladdenlongevityshop.com and use the promo code “podcast10”, you get 10% off your order. And this code isn't only good for our H2, but it's also good for all the supplements we carry. So, “podcast10” at gladdenlongevityshop.com.


Dr. Jeffrey Gladden: Yeah, one of the other things that I use it for routinely is when I'm about to go on a mountain bike ride, and I will say this, that if I go on a long mountain bike ride, I will take one prior, I'll take one during, and I'll take one after. And some of the iron men that we've worked with have said that when they're doing an iron man, they'll take it three or four times throughout the race, and their comment is that it's taking out the old battery and putting in a new one. It really rejuvenates your body's ability to perform when you're doing a more extended athletic activity. So, think about that too. If you want to go do a longer hike or whatever else, take it with you.


Steve Reiter: So, gladdenlongevityshop.com, enter “podcast10” for 10% off your order.


Dr. Jeffrey Gladden: H2 molecular hydrogen, it's low-hanging fruit on your quest to make 100 the new 30.


So, I will also add that the Vivoo app, it is possible to link up like your Oura ring or your Whoop or maybe your Garmin or whatever other trackers you have, I think, and dump that data in there. But I think it has to go through... You were telling us before the podcast I think it has to go through Apple Health or Google Health as an intermediary to get it onto the Vivoo platform. Is that correct?


Melisa Karabeyoglu: Yeah, that is correct. If you have your ring and your [inaudible 00:35:51] stuff logged onto Google or Apple Health, and you also have your Vivoo paired with that, which is really simple from our app, then they can all sync, and then it shows you how much calories you've been spending in a day, and also it's really cool because you're like: "You've been burning this many calories, and your sodium is low." And then you're like: "Ah-ha, now I get it. I have to hydrate after I exercise with something, electrolyte water."


Dr. Jeffrey Gladden: And you can see your strain score. So, if you're an athlete, as many of you are, then you can see your strain score. You know what environment you were exercising in, whether it was in a gym or outdoors or in the cold or in the heat. And you can start to learn and anticipate your needs. I think one of the best things about something like this is it can actually move you from being reactive to being proactive. So, if you know you're about to go out and do this, and you're going to come back dehydrated, well, let me hydrate extra before I go out and let me hydrate during, so that when I get back... The goal is not to come back dehydrated, so I know how much I should drink. The goal is to come back and not have to hydrate very much. So, it's about hydration all the way through.


Because if you're an athlete, performance really drops off with several things. One is continued exertion, of course, but dehydration is a big stimulus for decreased performance, as our drops in electrolytes. Your body reads those changes and says: "Okay, the brain is going to shut down the muscles because we're starting to overheat the boiler here. We're starting to overcook the muscles, or we're starting to work on a depleted schedule here of electrolytes and nutrients." And so, it's your brain that actually controls your ability to perform.


So, if you're anticipating that and able to use a device like this to learn how to preempt that, you'll be able to perform better, whether it's skiing or whether it's playing golf or whatever else you might enjoy doing. So, that's cool too. I like taking this from the reactive into the preemptive mode here.


Melisa Karabeyoglu: That's excellent. I think it really does motivate you to take immediate action. And I think that's really great what you are saying. I think a lot of individuals think: "I'm going to hydrate right now after my workout." But you're saying if you can know that data before and then hydrate throughout and right before, then after-


Dr. Jeffrey Gladden: Exactly.


Melisa Karabeyoglu: ... you won't have to because there's only so much you can absorb, and it puts a lot of strain on your body actually-


Dr. Jeffrey Gladden: That's right.


Melisa Karabeyoglu: ... to do.


Dr. Jeffrey Gladden: That's right.


Melisa Karabeyoglu: So, that's really interesting.

Dec 29, 2022

You can listen to this podcast by clicking the link below.

Episode #47

Episode #47 - Cont'd

Dr. Jeffrey Gladden: Yeah, we're better to fuel ourselves continually than we are to just do a big dump, either at the beginning or the end or the middle. You see that in people that do endurance racing. They're fueling all the way along. It's not like they're trying to get a big load in the beginning and have that carry them. So, I think there's a lot of wisdom in that. Could be fascinating, quite honestly. I'm thinking about mountain biking. Just stop by the side of the trail, urinate on a strip and test it in the middle of a ride and see what's happening now. That would be actually fascinating.


Melisa Karabeyoglu: So, I think with these biohacking tools, it's really cool you get to play around and see. I mean, just like with your ring, you can sleep one night differently on one side and see how it affects you. Same thing with the strips. I get really excited. I take them when I work out. I take them... It changes a lot. For women, throughout the month, our hormones change, and so does our absorption rates. So, I love that-


Dr. Jeffrey Gladden: Tell us about how it is modulated through your cycle. Tell us a little bit about that, if you don't mind.


Melisa Karabeyoglu: So, we were mentioning magnesium, and that's a really important mineral for many different reasons. But a lot of research shows that supplementing with magnesium or, even better, eating a magnesium-rich diet right before your menstruation and also for menopause, it really can help alleviate the symptoms. And that's just because it's really helpful for your muscles. The relaxation and contraction of your muscles and all of your organs are muscles.


Dr. Jeffrey Gladden: Fewer cramps and things like that, exactly.


Melisa Karabeyoglu: Exactly. So, a lot of research is showing that, unfortunately, I see so many individuals still take pain-relieving medication when they have pain from their menstruation cycle. And, of course, that is a signal that something in your diet and lifestyle is giving you cramps. It is not natural to have very heavy bleeding or very heavy cramps. A lot of research is showing that that is just a modern-day issue. A lot of individuals back in the day never had such cramps, and that's just because there's just more toxins in our bodies, and it's overwhelming for your body during your menstrual cycle to let go of so much, so it's giving you cramps, and having magnesium in your diet.


Dr. Jeffrey Gladden: Right. I get that. And magnesium is very important for muscle relaxation. It's also good for sleep, it's also good for recovery from exercise and-


Melisa Karabeyoglu: Nerves. 


Dr. Jeffrey Gladden: Nerves, yeah. It's calming the nervous system, and it's also good for calming down cardiac arrhythmias, and it's also good for decreasing menstrual cramps. We've known that. 


Melisa Karabeyoglu: Yeah. 


Dr. Jeffrey Gladden: I'm curious to know if you were to go through a month and test every day, and I'm sure you've probably done this or something analogous to it, are there fluctuations at various points in the month when you're retaining more fluid, when you're releasing more fluid, when you're premenstrual, when you're menstrual, have you seen actual patterns there? Would it be interesting for the audience to understand some of that?


Melisa Karabeyoglu: So, most of the individuals in the audience may know that during premenstrual cycle and the female menstrual cycle is made up of different weeks, and we... It's similar to the lunar cycle, actually. We used to follow the moon.


Dr. Jeffrey Gladden: That's right.


Melisa Karabeyoglu: So, premenstrual cycle, and sorry, right, PMS, right before we menstruate, our body holds onto a lot of fluid, and we generally are retaining more water. Of course, because I know this, I hydrate even more, and I decrease any kind of fluid-retaining foods, or I eat lots of foods like parsley, which is our dandelion route, which is naturally a diuretic, and that's a balance. But there's actually a lot of really interesting research done on how to naturally balance your cycle with different grains. And I've seized, and I tested that out for a couple of months, and I found amazing results by Dr... Sorry, she's not a doctor, but she is an expert in the field.


Alisa Vitti. She also went to Hopkins, she's one of my colleagues. She wrote Flo. So, I think with men, because men, their hormones are based on 24 hours, they're similar to the sun, and their hormones are consistent every single day of the year, 365, with women, it varies so much. And as more and more females rise up to powers of research and the medicine field, and a lot of people are speaking more, we're starting to realize that we have completely different needs and our needs change all the time throughout our month. 

And it may be overwhelming at first to a lot of women to hear this, but it's actually a gift because it allows you to have more power and learn more about your body, and you have different strengths throughout your cycle.


Dr. Jeffrey Gladden: I would think this would be incredibly empowering if you're a menstruating woman and if you're an athlete, for sure. But even if you're not, I think this would be incredibly empowering because to be able to track it for several months and, all of a sudden, start to see the patterns of what's happening and then move into the preemptive mode, it's like: "Okay, I'm coming into the third week, I know that I need to be doing this." Or: "Now I'm premenstrual, I need to be eating more magnesium and avoiding high sodium foods and maybe doing some things that are natural diuretics," and things that you were commenting on, I think that'd be incredibly empowering, quite honestly, rather than just being the victim of your body. I mean, who wants to be the victim of their body?


Melisa Karabeyoglu: Yes.


Dr. Jeffrey Gladden: So, that's very, very cool stuff. I think that it's part of the beauty of this real-time feedback. I mean, I wish we had more sensors. I mean, I wish we could know more about ourselves. And so, to that point, is Vivoo planning to add more test results that we can get, or what's going to happen? 


Melisa Karabeyoglu: Yes. So, we are trying to add more results to our parameters. And we're also right now developing certain tools that you can actually use in your home, so you wouldn't necessarily have to use the strip, which is easy enough, but it would be already built into your bathroom. So, we're in that stage right now; we're still in the research, the R&D development.


Dr. Jeffrey Gladden: You'd have a Vivoo toilet. Is that what you're saying? Or what are you trying to say?


Melisa Karabeyoglu: Something similar to that, fancier than the Japanese toilets. Yeah. 


Dr. Jeffrey Gladden: Okay. All right. It'd be interesting to see what the plans for that look like. Yeah, I think the strips sound a lot more portable, so I'm just curious, with the strips, are you planning to add additional features to that or additional things that you can measure? 


Melisa Karabeyoglu: So, we are looking at adding that. Right now, ketones are one of our most popular parameters just because we have a very large community of ketogenic and similar types... Paleo, ketogenic and just individuals who are trying to manage their ketones for fitness. So, in addition to those, we are currently developing... And it's more just about... It takes a long time just to develop them and also have them approved by the FDA, so we're working on those right now. But right now, we have nine. So, I'm just going to count them again for our listeners who may have joined in at the end of the podcast.


We have vitamin C, magnesium, and calcium, we also have salinity, so sodium, which is usually the most eye-opening, hydration, which you scored accidentally on, and we also have oxidative stress. So, that's looking at your inflammation. Protein, so protein might sound confusing. It's not really about how much protein you're eating. It's more about if we see proteins in the urine, and we really don't want to see that. So, we also can call the protein parameter also kidney health. So, a lot of individuals, if they're straining their kidneys or if they're stressed, they might sometimes see that or if they're dehydrated.


Dr. Jeffrey Gladden: I think most of the audience understands that my kidneys were damaged when I was five years old from strep throat and post-strep glomerulonephritis. And so, my kidney function has always been what I would call borderline, and I've always had some protein in the urine. What was interesting was to see that on the Vivoo test, the protein was in a low range. It wasn't-


Melisa Karabeyoglu: Great.


Dr. Jeffrey Gladden: ... zero, but it was in a low range. And I thought: "Well, that's kind of reassuring because you wake up every day wondering… I wonder how my kidneys are doing." And so, to beget some feedback on that is kind of reassuring. So, if anybody else rather has some kidney issues for one reason or another, this can be helpful to you for that. And the-


Melisa Karabeyoglu: Yeah, that must be very reassuring. Excuse me. 


Dr. Jeffrey Gladden: Yeah, no, it's good. The oxidative stress is interesting too. So, I think that it's easy for enthusiastic athletes to overdo it, right? 


Melisa Karabeyoglu: Oh yeah.


Dr. Jeffrey Gladden: We start to think that more is better. If I can run three miles today, I want to run five miles tomorrow, and I want to run seven miles this weekend. More is always better. But really, all of biology is really this economy of balance, and really there are Goldilocks zones for virtually everything. And so, utilizing something like this to also tell you when you've exceeded what's actually healthy for yourself, whether it's any activity or anything else, I think is another very useful thing. So, people, they contest this several times, multiple times during the day, right?


Melisa Karabeyoglu: Yes.


Dr. Jeffrey Gladden: To see where they're at.


Melisa Karabeyoglu: Yeah. And I also, just before I forget, we are offering our listeners today for this podcast a 30% off discount rate. If they go to vivoo.io and they use a code “longevity”, so for your podcast, that's our code, they will get 30% off. So, it depends on the pack you get, but you can use it every day. We always recommend that if you're trying to see how certain daily lifestyle changes are affecting your internal health, to do it every day at the same time. So, we don't recommend the first urine. 


So, the first time you wake up and use a bathroom; usually, your urine is concentrated. So, we recommend either the second or the third time you visit the bathroom in the morning. Some individuals who work really strenuous jobs, they only can do in the night, et cetera. But if you can, I would recommend for you to get a one-month pack, and then you can, like were saying, test throughout different exercises. So, I used to be just the person I was, very high-achieving, I used to overdo it all the time with exercise, and then I realized with Vivoo that I was giving myself so much oxidative stress by overworking myself out in the gym or in any kind of exercise outlet that probably with my inflammation, my body wasn't having enough time to heal.


So, that's why I think the oxidative stress is a really interesting one. I also think it's really interesting that when you don't sleep enough, and if you were to pair your ring also to Google or Apple Health and then also with Vivoo, you could see, for example, when I don't sleep enough and every individual varies, but for me, I need at least seven or eight hours, my oxidative stress immediately goes up high no matter what I do.


Dr. Jeffrey Gladden: Interesting.


Melisa Karabeyoglu: So, even if I'm eating great and I'm drinking, and I'm having a very relaxing time at the beach, I also live by a beach during the summer and stuff, even if I'm not sleeping enough, it goes really high, my oxidative stress. So, I notice that for my body, sleep is really important. However, for Tom or Sarah, that might be completely different. Our internal makeup is very different.


Dr. Jeffrey Gladden: When I think about longevity, Melissa, I think the oxidative stress measurement is, all of them are important, but I think that's one of the real important ones because we know that in the aging process, inflammation builds up from a variety of different reasons. We'll call them underlying reasons. Increasing senescent cells, increasing altered intracellular communication. We know that inflammatory cytokines start to increase. We know that our ability to actually shut down inflammation, which is genetically programmed, also some of us have more ability than others to do that. 


But nonetheless, as we age, we all become more inflamed, and the whole concept of inflammation. Well, why is inflammation damaging? Inflammation is damaging because it increases oxidative stress. So, if you actually have a metric for looking at your oxidative stress, this is really one of the best age-hacking metrics that you can have. So, I was really pleased to see that you have it on there for oxidative stress. And, of course, we're huge fans of hydrogen to be able to balance oxidative stress. And mine came out of 10, and I don't know if that's because I'm drinking hydrogen, but I'm going to try it with and without and see how that plays. And the listeners could do the same thing. It'd be interesting to look at that.


Melisa Karabeyoglu: Yeah, it's very interesting. And you might think: "Why am I always craving apples, or why am I...” It's your body's internal cues wanting certain components in your diet or your lifestyle to kind of balance what's going in inside. And probably, your hydrogen water is really having a big impact on not only your hydration but also your oxidative stress. So, that's fantastic. 


Dr. Jeffrey Gladden: Yep, exactly. Well, this has been great, Melissa. It's really been a pleasure chatting with you. Very informative.


Melisa Karabeyoglu: Thank you. If you do require-


Dr. Jeffrey Gladden: Steve, do you have any other last questions or anything that's coming to mind for you?


Steve Reiter: Melisa, how many test strips does someone get when they sign up per month?


Melisa Karabeyoglu: That's a great question, Steve. So, it totally depends on the packet you choose to purchase. On our website, www.vivoo, so it's V-I-V-O-O, O-O dot I-O. There's different options. We also sell on Amazon, but if you want to get the 30% off, you would have to go to our website and type in “longevity”. So, we do have an option of one week, so that's seven, and then you can get two weeks and a month. And then some of individuals actually, a lot of our athletes do sign up for longer than that, month-to-month or a year-supply. So, it can totally depend on what you want, Steve.


Dr. Jeffrey Gladden: So, with a year-supply, you get 365 strips, is that what you're saying?


Melisa Karabeyoglu: So, yeah, it would depend on how often you want to test your year-supply. You would sign up for a monthly subscription, it wouldn't send you 365 strips, I think. That would be comical.


Dr. Jeffrey Gladden: But here's the point. What if in your first month, you want to test five times a day? So, you would sign up for five months. Is that what you're saying? To get that number of strips?


Melisa Karabeyoglu: Yeah. You would sign up for five months worth. 


Dr. Jeffrey Gladden: Okay.


Melisa Karabeyoglu: Yeah, 30 is for a month. So, assuming that an individual is going to test every day because that's really what our research shows, that's how long it really takes our clients to make changes to their lifestyle, and they only really see when they are taking it every day, because our lives do kind of average the same within a week, but it does really depend on every day. Like I said, you might travel one day, and then another day you might go out for drinks with your friend, another day you might go into the sauna two times, et cetera. So, we try and look at it every day.


Steve Reiter: And then how quickly after someone uses the strip do you test the results?


Melisa Karabeyoglu: So, for example, if you were to rip the strip open and then you were to urinate on it, you only have to urinate for two, three seconds. And then after that, you wait a minute and a half, so 90 seconds. And then you take your phone, and after you download the app, there's a QR code, but you can also go to the app store and download it. You would scan it, and then once you scan the barcode, instantaneously, it's going to log onto your phone. And then what's cool is, according to your individualized data, it's going to give you personalized recommendations on plant-based.


So, for me, when my calcium is low, it's going to tell me to eat more greens, but it's not going to tell me to drink more milk, for instance. It's going to look at your age, your gender, and your diet, and lifestyle and give you personalized recommendations. So, quite quick to answer your question, within a minute and a half in total.


Steve Reiter: And then the code is “longevity” at Vivoo? 


Melisa Karabeyoglu: Yes. 


Steve Reiter: V-I-V-O-O, dot I-O?


Melisa Karabeyoglu: Yes, “longevity” to get 30% off of your orders. That's a really great deal that we're giving out today.


Dr. Jeffrey Gladden: Great. Well, it's been a pleasure. Thanks so much for... I know you're coming to us from Europe, someplace. Are you in Turkey or? Where are you?


Melisa Karabeyoglu: Yeah, I'm in Turkey today, yeah.


Dr. Jeffrey Gladden: Okay. Turkey today. All right. Well, who knows where you'll be tomorrow? All right. Well, great. Well, have fun, and we will implement this and see what we learned. We're excited to do that.


Melisa Karabeyoglu: Yeah, we would love to hear your feedback. Thank you so much for this. It's been really an honor to speak with you here today, and you're very motivating. I'm going to continue to look at your websites. Very, very inspirational.


Dr. Jeffrey Gladden: Great. Love it. Thanks.


Steve Reiter: Thank you for listening to this week's episode of the Gladden Longevity Podcast. If you would like more information on what we've discussed or other topics, please reference the show notes or go to gladdenlongevitypodcast.com. You can also find us on Instagram, Facebook, and Twitter by searching Gladden Longevity. If you've enjoyed this podcast, please subscribe to get future episodes delivered to you and share our podcast or this episode with someone in your life who may find benefit. Thank you for listening. We'll be back next week with another exciting episode. 


The Gladden Longevity Podcast is provided for informational purposes only. It does not constitute medical advice. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The use of any information and materials linked to this podcast is at the listener's own risk.

Episode #47
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